Tuesday, October 23, 2007 : 1:40 p.m.

Fate of Pharmaceutical Residues during Ground Water Recharge: Final Results from the Nasri Project (2002-2005)

Thomas Heberer, Ph.D.1, Andy Mechlinski2 and Britta Fanck2, (1)Federal Institute for Risk Assessment, (2)Technical University of Berlin

Between 2002 and 2005, the occurrence and fate of different pharmaceutical residues including analgesics, antibiotics, anti-epileptic drugs, blood-lipid regulators, estrogenic steroids, X-ray contrast media and several drug metabolites during recharge of surface water under the influence of municipal sewage discharges were investigated in Berlin, Germany. The research was conducted in terms of an interdisciplinary project entitled NASRI (Natural and Artificial Systems for Recharge and Infiltration) investigating the transport and fate of drug residues in soil column studies and at various transects with monitoring wells drilled at different bank filtration sites and at a facility for groundwater replenishment using contaminated surface water for groundwater recharge.

It was shown that residues of various pharmaceutical residues including AMDOPH, clofibric acid, diclofenac, propyphenazone, carbamazepine, primidone, sulfamethoxazole are leaching from the surface water into groundwater also occurring at trace levels in the receiving water-supply wells. Other compounds such as indometacin, bezafibrate, some antibiotics, and estrogenic steroids were also detected in the surface water but efficiently removed by bank filtration and not detected downstream from the first two monitoring wells.

The capacity for the removal of the individual residues could be linked to the hydro-geochemical conditions prevailing in the respective groundwater infiltration zones or aquifers. It was not possible to assign removal capacities to specific structural properties of common compound classes. However, for some compounds redox conditions and residence times for a preferential and often complete removal of the individual compound were identified and will be reported. In conclusion, bank filtration was found to decrease the concentrations of some drug residues or even to remove selected compounds. However, a complete removal of all potential drug residues by bank filtration may not be guaranteed.

Thomas Heberer, Ph.D., Federal Institute for Risk Assessment Dr. Thomas Heberer graduated and received his PhD degree in food chemistry at the TU Berlin where he is teaching as an associate professor. In 2004, he joined the German Federal Institute for Risk Assessment being appointed head of the Department for Residues of Medicinal Products. He was working in more than 25 research projects, published more than 75 papers in scientific journals or books and received the science award of the Water Chemistry Division of the German Chemical Society for his “innovative research on the occurrence, analysis, fate and removal of pharmaceutical residues in the aquatic environment”.


6th International Conference on Pharmaceuticals and Enocrine Disrupting Chemicals in Water